Invitrogen™ Silencer™ Select Human Drug Transporter siRNA Library

Invitrogen™ Silencer™ Select Human Drug Transporter siRNA Library

Transporter proteins play a key role in pharmacology, affecting how drugs are moved across cellular membranes. The Silencer™ Select Human Drug Transporter siRNA Library provides investigators with a focused RNAi screening platform targeting the most up-to-date transporter genes important in entry and extrusion of drugs into and out of cells. Target genes include those impacting absorption, distribution, metabolism and excretion of many drugs. The Silencer Select Human Drug Transporter siRNA Library contains 297 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 99 drug transporter genes. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps to maximize the efficacy, specificity and potency to RNAi screens against drug transporter genes.

Features

• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 297 total siRNAs targeting 99 genes plated onto 96-well plates (6 plates)