Invitrogen™ Silencer™ Select Human Cell Cycle Regulation siRNA Library

Invitrogen™ Silencer™ Select Human Cell Cycle Regulation siRNA Library

Proteins that regulate cell division are crucial for controlling cell growth and are therefore potentially important drug targets. The Silencer™ Select Human Cell Cycle Regulation siRNA Library contains 4,417 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 1,471 genes. These siRNA gene targets include cyclin-dependent kinases, or CDKs, which are crucial for cell cycle progression, regulators of cell cycle progression such as CIP/KIP family proteins and members of the INK4 family of cell cycle inhibitors, proteins in the retinoblastoma family, and DNA replication factors such as the cell division cycle proteins (CDCs). This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading design algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps to ensure the maximum efficacy, specificity and potency required for RNAi screens against cell cycle regulation studies.

Features

• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 4413 total siRNAs targeting 1471 genes plated onto 96-well plates (51 plates)