Detection of NPM1 A, B & D mutation
Main indication:
AML (Acute Myeloid Leukemia).
Test usage:
This test is used to detect NPM1 mutations, the most commonly known genetic lesion in AML, occurring in about 30% of adult de novo cases, and 50-60% of AMLs with normal karyotype. NPM1 mutations in the absence of FLT3 mutations confer a more favorable prognosis in AML.