PML-RARA (detection MRD), (PCR)

Nested PCR for high sensitive PML-RARA bcr1 and bcr3 detection 

Main indication:

AML-M3 (detection-MRD).

Test usage:

This test quantitatively detects all three PML/RARA transcript variants in peripheral blood and bone marrow. Testing for PML/RARA can assist in the diagnosis, clinical management, and monitoring of APL. Greater than 95% of acute promyelocytic leukemia (APL) cases harbor a t(15;17) translocation. This rearrangement results in the fusion of the PML and retinoic acid receptor alpha (RARA) genes located on chromosomes 15 and 17 respectively. Three breakpoint regions within the PML gene can be involved, resulting in three possible PML/RARA fusion types: bcr1 (long), bcr2 (variable), and bcr3 (short).