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PDGFRA D842V, (PCR)

On demand
Order number : ON-P02
(Ex-work price)
$ On demand

Detection of c-kit D842V mutation on Exon 18 


Main indication:

GIST with Negative c-kit IHC and positive PDGFRA IHC.


Test usage:

This test is used to detect D842V the most common PDGFRA mutation, which is associated with imatinib therapy resistance. PDGFRA gene mutations occur in approximately 30% of gastrointestinal stromal tumors (GISTs) that are wild type for KIT mutation, and in 7% of GISTs overall. PDGFRA and KIT mutations are mutually exclusive in GISTs. The vast majority of PDGFRA gene mutations involve exons 12 and 18, and invariably result in constitutive activation of the PDGFRA protein. 

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