Thermo Scientific™ CL(PEG)12 Carboxy-PEG-Lipoamide Compound

Thermo Scientific™ CL(PEG)12 Carboxy-PEG-Lipoamide Compound

Thermo Scientific Pierce CL(PEG)12, or carboxy-PEG12-lipoamide, is a carboxyl- and bidentate thiol-terminated compound that contains a 4-unit polyethylene glycol (PEG) spacer and is used to modify quantum dots, and silver or gold surfaces and particles.

CL(PEG)12 is a bidentate thiol-terminated and carboxylic acid pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate 'handles' for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides.

Features

• Metal-binding—terminal bidentate thiol reacts spontaneously with silver, gold and other metal surfaces to form strong dative bonds
• Carboxylate—terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry
• Polyethylene glycol—PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods
• Spacer arm—12-unit PEG spacer makes the reagent nearly 56 angstroms long, minimizing steric hindrance for protein immobilization and binding assays