Thermo Scientific™ Sulfo-GMBS (N-γ-maleimidobutyryl-oxysulfosuccinimide ester)

Thermo Scientific™ Sulfo-GMBS (N-γ-maleimidobutyryl-oxysulfosuccinimide ester)

Thermo Scientific Pierce Sulfo-GMBS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).

Features

• Reactive groups: sulfo-NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• Non-cleavable
• Water-soluble (compare to GMBS)
• Has a low potential for illiciting crosslinker immune response, ensuring that the primary response to the antigen-carrier protein conjugate is not diluted by a response against a determinant on the crosslinker
• GMBS and Sulfo-GMBS are reported to be less immunogenic than SMCC