Thermo Scientific™ SureQuant™ RAS Isoform Relative Quantitation Module

Thermo Scientific™ SureQuant™ RAS Isoform Relative Quantitation Module

The Thermo Scientific SureQuant RAS Isoform Relative Quantitation Module provides a complete quantitation solution for the analysis of key RAS expression using mass spectrometry (MS).

The RAS family of GTPase proteins modulates two key signaling pathways involved in cell growth and proliferation: the MAPK and PI3K pathways. Aberrant activation of the RAS proteins promotes constitutive activation of cell growth and proliferation that can result in cancer. Mutations in the NRAS, KRAS, and HRAS oncogenes are the most common mutations in human cancer. This kit is ideal for monitoring expression levels of the three isoforms in a single assay. The ability to simultaneously monitor and quantitate in a single sample is a powerful tool for assessment of normal and abnormal pathway signaling.

For use with: Thermo Scientific™ Q Exactive Mass Spectrometer, Mass Spectrometer

Features

• Complete—contains validated AQUA HeavyPeptide mix, diluent, matrix, and system suitability standard including optimized acquisition and analysis methods
• Validated—peptides rigorously tested for successful quantitation of each target peptide
• Multiplex—able to quantitate NRAS, KRAS, and HRAS isoforms