Invitrogen™ Silencer™ Human DNA Damage Response siRNA Library

Invitrogen™ Silencer™ Human DNA Damage Response siRNA Library

DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations. The Silencer™ Human DNA Damage Response siRNA Library contains 1,725 Ambion™ Silencer siRNAs targeting 575 genes for performing RNAi screens against known DNA damage response pathways. The library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). Utilizing Ambion Silencer technology built on stringent bioinformatics to enable target specificity and siRNA potency, the Silencer Human DNA Damage Response siRNA Library is an ideal solution for focused and cost-effective RNAi screens targeting cellular pathways that sense, signal and repair DNA lesions following DNA damage.

Features

• Comprehensive—Expedite functional gene discovery with pre-defined Silencer Human GPCR siRNA Library
• Reliable—Increase target screening accuracy with three individual siRNAs per gene target
• Effective—Reduce off target impacts at low concentrations with proven Ambion Silencer siRNA design
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 1725 total siRNAs targeting 575 genes plated onto 96-well plates (21 plates)