Invitrogen™ Silencer™ Select Human Ubiquitin siRNA Library

Invitrogen™ Silencer™ Select Human Ubiquitin siRNA Library

Ubiquitination is a post-translational enzymatic modification that is essential to a wide array of cellular processes. These include immunological functions, apoptosis, biogenesis, DNA transcription and repair, cell cycle and division, cellular stress response, modulation of cell receptors and neural or muscular degeneration as well as disease and diagnostic-related processes. The Silencer™ Select Human Ubiquitin siRNA Library contains 2,943 Ambion™ Silencer Select siRNA s targeting 981 genes, including ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases. This library of highly potent, chemically-modified siRNAs was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps ensure the efficacy, specificity and potency required for RNAi screening against ubiquitin signaling.

Features

• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 2943 total siRNAs targeting 981 genes plated onto 96-well plates (36 plates)