KRAS, (PCR)

Detection of the most common 29 KRAS mutations in codons 12,13,59,60,61.117 and 146  

Main indication:

NSCLC \ CRC.

Test usage:

Activating mutations in the KRAS gene occur in approximately 40% of colorectal carcinomas, 20% of non-small cell lung cancers, and a variety of other human cancers. Mutations are predominantly single nucleotide substitutions (missense mutations), most frequently occurring within codons 12 and 13 of exon 2. Less commonly, mutations occur within codon 61 of exon 3 and codons 117 and 146 of exon 4. Collectively these mutations have been associated with a limited clinical response to epidermal growth factor receptor (EGFR) targeted therapies in lung and colorectal cancers, and may also have prognostic implications.