Thermo Scientific™ MS(PEG)24 Methyl-PEG-NHS-Ester Reagent
On demandThermo Scientific™ MS(PEG)24 Methyl-PEG-NHS-Ester Reagent
Thermo Scientific Pierce MS(PEG)24 is a methyl-terminated, polyethylene glycol compound activated as an NHS ester for covalent pegylation of primary amines on proteins (e.g., lysines) or assay surfaces.
MS(PEG)n is the abbreviation for a set of compounds having polyethylene glycol (PEG) spacers with methyl (—CH3) and amine-reactive NHS-ester groups at opposite ends. The unbranched, hydrophilic, discrete-length molecules have the form Methyl-PEGn-NHS Ester, where the subscript 'n' denotes 4, 8, 12, or 24 ethylene glycol units. The N-hydroxysuccinimide (NHS) ester is spontaneously reactive with primary amines (—NH2), providing for efficient PEGylation of proteins, peptides and other amine-containing molecules or surfaces.
Features
- 24 PEG units, spacer arm 88.2 Å
- NHS-activated for efficient PEGylation of primary amines at pH 7-9; reaction of NHS-ester group results in formation of stable, irreversible amide bonds
- Fully characterized PEGylation reagents with defined PEG chain lengths; molecules of discrete molecular weight for consistency of performance in protein-modification applications
- PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Easy-to-follow instructions increase the likelihood of a successful outcome
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